Background: Behcet’ s syndrome is a disease with different aspects in its clinical manifestations. The purpose of this study was to evaluate the simultaneous presence of oral mucosal and ophthalmologic lesions in patients with Behcet’ s syndrome. Methods: From April 2012 to December 2014, 50 cases of Behcet’ s syndrome who referred to the Departments of Ophtalmology, Oral Diseases and Infectious Diseases of Babol University Medical Sciences were entered into the study. The diagnosis of the disease was performed using the Iranian criteria for the diagnosis of Behcet’ s syndrome. The demographic findings as well as clinical manifestations were recorded. Results: Thirt-six (72%) were males and 14 (28%) were females. The mean age of the patients was 35. 6± 9 years. Oral aphthous (94%), ocular lesion (76%) and genital ulcers (70%) were the most clinical findings. The clinical onset of the disease in 43 (86%) was oral lesions and in 5 (10%) was ocular lesions. Among the forty-eight cases with oral lesions, 77% had ocular lesions concurrently. HLA-B5 was positive in 35 (70%) cases. Ocular lesion was seen in 33 of 35 (91. 4%) cases versus 6 of 15 (40%) with HLA-B5 positive and negative cases, respectively (p<0. 05). Oral lesion was seen in 94. 3% cases with positive HLA-B5 and in 100% cases with negative HLA-B5 (p>0. 05). Conclusions: The results show that concurrent ophthalmic and oral lesions in Behcet’ s syndrome are relatively high. HLA-B5 positive cases are associated with more ophthalmologic lesions.

Background: Behcet's Disease (BD) is one of the chronic inflammatory diseases with unknown etiology. The relationship between infectious agents and BD has not been clearly identified yet. Human cytomegalovirus (HCMV) causes a primary infection in the first years of life and remains latent in various tissues and cells. This study aimed to find out the frequency of HCMV among BD patients. Methods: In this cross-sectional study, serum samples from 103 BD patients were analyzed for HCMV by molecular and serological tests. The results were analyzed by IBM SPSS version 20. Results: The mean age of BD patients was 38. 67± 8. 82, and 53% (54/103) were male. The mean duration of BD was 18. 42± 6. 12 years. HCMV IgG antibody was found in 96% and 94% of males and females, respectively, and the IgM antibody was positive only in one male patient. HCMV DNA was not detected in the samples. Conclusion: Our result showed, there is no evidence of Cytomegalovirus infection among Behcet's patients. Like other studies IgG antibodies against CMV are prominent among the general population. and Behcet patients. While, IgM against HCMV was positive only in one patients. But, no CMV-DNA detected among 103 Behcet patients. However, the absence of the virus genome in a positive IgM person can be due to the Short-term DNAemia or due to rheumatoid factor interference. In addition, there is a time lag between primary infection and IgM antibody production (IgM level can remain undetectable because of delayed seroconversion owing to immunosuppressive agents). IgM antibodies can also persist for a long time after infection in some healthy individuals.

Hydatid cyst is a zoonotic infection caused by the larval stage of the worm Echinococcus granulosus. Although any organ could be infected, the involvement of the bone, brain and heart are uncommon. The brain involvement Prevalence varies in the hydatid disease. We present a 27-year-old man with 10 years history of Behcet disease and with an unusual occurrence of brain hydatidosis, diagnosed by MRI and histological findings. Removal of the cyst by surgery was successfully performed and Albendazole was administered for 4 weeks after the surgery (400 mg two times daily) accompanied MLP.

Background: Behcet syndrome is a recurrent inflammatory disorder that frequently involves the ocular system. The purpose of this study was to determine the frequency of ocular involvement in cases of Behcet's disease in Babol, north of Iran. Methods: From April 2003 to December 2009, 100 cases of Behcet's disease who were admitted at the Department of Ophthalmology and Internal Medicine of Babol University of Medical Sciences, in Babol, were studied. The diagnosis of the disease was performed by the Iranian criteria for the diagnosis of the Behcet's disease. The demographic data, clinical manifestations as well as the frequency of ocular involvement were recorded and analyzed. Results: Sixty-one (61%) were male and 31 (31%) were female. The mean age of the male patients was 28.2 and the female patients were 27.5 years. The most common clinical findings were oral aphtose (90%) followed with ocular and genital involvement. In ten cases ocular involvement was the sole initial clinical symptom. Among the 70 cases with ocular involvement, bilateral involvement was seen in 78.6% and unilateral involvement in 21.4% cases. HLA- B5 was positive in fifty two (74.2%) cases with ocular involvement, whereas 18 (25.7%) with ocular involvement had negative HLA- B5.Conclusion: The results show that the frequency of ocular involvement in patients with Behcet's disease is relatively high. Investigation of eye involvement in subjects with recurrent oral or genital ulcers is recommended.

Background: Behcet"s disease is a recurrent, chronic and multi-systemic disease which is determined by mucocutaneous manifestations. It spreads all over the world. The most common areas are in the Middle East, Mediterranean and Far East. Objective: The aim of this study was to determine the frequency of clinical manifestations of Behcet"s disease in patients admitted to dermatology ward of Sina Hospital in Hamadan City in 1991-1999. Patients & Methods: This study was a descriptive retrospective cross-sectional study which the essential information including sex, age and clinical manifestations were gathered by referring to the patients" files. Then the obtained information were analyzed by EPI Info6 Software. Results: twenty-eight patients were identified. Thirteen patients (46.6%) were female and 15 patients (53.6%) were male. The most common age was in the third decade. The average age of the patients at the. beginning of disease was 31.89±12.95 years. Skin involvement was observed in 11 patients (39.9%). Nine patients (32.1%) had folliculitis, 5 patients (17.9%) had papulopustular lesions, 2 patients (7.1 %) had erythema nodosum like lesions. Conclusion: This study showed that skin involvement (particularly erythema nodosum like lesions, papulopustular lesions and positive pathergy test) and also arthicular symptoms were less common in patients in Hamadan than other parts of world. But the frequency of other clinical manifestations of Behcet"s disease were nearly equal to other studies.

Behcet‘s syndrome, a major cause of posterior uveitis and visual loss in the Third World, has probably existed for more than 4000 years. It is a multisystem, inflammatory disorder whose principal manifestations are oral and genital aphthosis as well as inflammation of the eye, skin, and joints. The principal causes of death are from vascular and neurological involvement. No etiological agent has yet been identified for the disease; current evidence suggests that the normal flora of mucosal tracts induce immunological hyper-reactivity in genetically predisposed individuals.

Background: Behcet disease is a vasculitis with mucocutaneous, ocular, arthritic, vascular, and other manifestations. Its neurologic manifestations (neuro-Behcet disease) are relatively rare, but they must be thoroughly investigated due to their grave prognosis.Review Summary: The frequency of neurologic manifestations, more common in tnale Behcet patients, is between 5% and 30%. Both the central and peripheral nervous systems can be involved. Central nervous system manifestations can be divided into 2 main groups: (1) parenchymal involvement, which includes brainstem involvement, hemispheric manifestations, spinal cord lesions, and meningoencephalitic presentations; (2) nonparenchymal involvement, including dural sinus thrombosis, arterial occlusion, and/ aneurysms. Peripheral neuropathy and myopathy are relatively rare. Cerebrospinal fluid analysis reveals pleocytosis and elevated protein levels. Magnetic resonance imaging is the investigation of choice which often reveals iso-/hypointense lesions in T1-weighted images and hyper intense lesions in T2-weighted images, mostly in the mesodiencephalic junction, cerebellar peduncles, and other parts the brainstem. Corticosteroids and adjuvant immunosuppressive therapy are used for parenchymal manifestations, and corticosteroids and anticoagulants are used for treatment of dural sinus thrombosis.Conclusion: Neuro-Behcet disease must be considered in the differential diagnosis of stroke in young adults, multiple sclerosis, movement disorders, intracranial hypertension, intracranial sinovenous occlusive diseases, and other neurologic syndromes.